A while ago I started a new project which allows a seamless integration of Node.js into the Domino server.
The project is hosted on GitHub: https://github.com/hasselbach/dominodejs
The Node.js server is running as a DOTS task, and under the hood the J2V8 project is used for the V8 integration.
Currently, the project is a pre alpha, and it it is more for fun than for profit. There are a lot of open questions about the architecture, but it shows what cool things can be done with Domino.